Aprea Therapeutics (NASDAQ:APRE – Get Free Report) and Aptevo Therapeutics (NASDAQ:APVO – Get Free Report) are both small-cap medical companies, but which is the superior investment? We will contrast the two businesses based on the strength of their analyst recommendations, valuation, institutional ownership, dividends, profitability, earnings and risk.
Profitability
This table compares Aprea Therapeutics and Aptevo Therapeutics’ net margins, return on equity and return on assets.
| Net Margins | Return on Equity | Return on Assets | |
| Aprea Therapeutics | -1,029.50% | -57.86% | -47.94% |
| Aptevo Therapeutics | N/A | -353.04% | -132.42% |
Insider & Institutional Ownership
34.2% of Aprea Therapeutics shares are owned by institutional investors. Comparatively, 8.1% of Aptevo Therapeutics shares are owned by institutional investors. 12.8% of Aprea Therapeutics shares are owned by insiders. Comparatively, 0.1% of Aptevo Therapeutics shares are owned by insiders. Strong institutional ownership is an indication that hedge funds, endowments and large money managers believe a company will outperform the market over the long term.
Risk & Volatility
Earnings & Valuation
This table compares Aprea Therapeutics and Aptevo Therapeutics”s top-line revenue, earnings per share and valuation.
| Gross Revenue | Price/Sales Ratio | Net Income | Earnings Per Share | Price/Earnings Ratio | |
| Aprea Therapeutics | $580,000.00 | 27.24 | -$14.29 million | ($2.81) | -1.04 |
| Aptevo Therapeutics | $3.11 million | 1.83 | -$17.41 million | N/A | N/A |
Aprea Therapeutics has higher earnings, but lower revenue than Aptevo Therapeutics.
Analyst Ratings
This is a breakdown of current recommendations and price targets for Aprea Therapeutics and Aptevo Therapeutics, as provided by MarketBeat.
| Sell Ratings | Hold Ratings | Buy Ratings | Strong Buy Ratings | Rating Score | |
| Aprea Therapeutics | 0 | 0 | 2 | 0 | 3.00 |
| Aptevo Therapeutics | 0 | 0 | 1 | 0 | 3.00 |
Aprea Therapeutics currently has a consensus target price of $15.50, indicating a potential upside of 432.65%. Aptevo Therapeutics has a consensus target price of $8.00, indicating a potential upside of 2,499.94%. Given Aptevo Therapeutics’ higher possible upside, analysts plainly believe Aptevo Therapeutics is more favorable than Aprea Therapeutics.
Summary
Aprea Therapeutics beats Aptevo Therapeutics on 7 of the 11 factors compared between the two stocks.
About Aprea Therapeutics
Aprea Therapeutics, Inc., a clinical-stage biopharmaceutical company, focuses on developing and commercializing novel synthetic lethality-based cancer therapeutics that targets DNA damage response pathways. Its lead product candidate is the ATRN-119 that is in Phase I clinical trials for treating advanced solid tumors. The company is also developing ATRN-1051 for the treatment of ovarian cancer; and APRE-DDRi for the treatment of advanced solid tumors. The company is headquartered in Doylestown, Pennsylvania.
About Aptevo Therapeutics
Aptevo Therapeutics Inc., a clinical-stage research and development biotechnology company, focuses on developing immunotherapeutic candidates for the treatment of various forms of cancer in the United States. It develops its products using ADAPTIR and ADAPTIR-FLEX platforms to generate monospecific, bispecific, and multi-specific antibody candidates capable of enhancing the human immune system against cancer cells. The company's lead clinical blood cancer candidate is APVO436 that is in Phase 1b/2 clinical trial for acute myelogenous leukemia. It is also developing ALG.APV-527, a novel investigational bispecific ADAPTIR candidate that is in Phase 1 clinical trial for NSCLC, head and neck, colorectal, pancreatic, breast, and other solid tumors; APVO603, a preclinical dual agonist bispecific ADAPTIR candidate for multiple solid tumors; APVO442, a novel bispecific candidate based on the ADAPTIR-FLEX platform technology for multiple solid tumors; and APVO711, a preclinical dual mechanism bispecific ADAPTIR candidate for prostate cancer. The company has a collaboration and option agreement with Alligator Bioscience AB to develop ALG.APV-527. Aptevo Therapeutics Inc. was incorporated in 2016 and is headquartered in Seattle, Washington.
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